Title: The association between the environmental endocrinedisruptors and Cardiovascular diseases: a systematic review and meta analysis

Abstract:

Background：Except for known cardiovascular risk factors, long-term exposure to environmental Endocrine disruptors (EEDs) has been proved to increase the risk of cardiovascular diseases (CVD), which are still controversial.
Objective:The aim of the study was to evaluate the relationship between CVD and EEDs which are most closely related to daily life .acomprehensively explore the associations between EEDs exposure and CVDfor the first time. Besides,.In addition, gender, age, body mass index (BMI), waist circumference (WC), total cholesterol (TC), high density lipoprotein (HDL), and low-density lipoprotein (LDL) were analyzed in subgroup for the first time.To explore the role of these specific variables in the impact of BPA on CVD risk.
Methods:The heterogeneity between different studies was qualitatively and quantitatively evaluated using Q test and I2 statistical magnitude, respectively in Stata12.0 software. Subgroup analysis was performed using chemical homologs, a previously unused grouping method, to extract data and perform meta-analysis to assess their exposure to CVD.
Results:Twenty-three literatures were enrolled with a total sample size of 40717. The results indicated that polychlorinated biphenyl（PCB）138, PCB153, and total PCB were the risk factors for CVD exposure (OR=1.26, 95%CI: 1.03-1.54; OR=1.17, 95%CI: 1.00-1.37; OR=1.50, 95%CI: 1.11-2.02). CVD risk had a statistical significance with organo-chlorine pesticide(OCPs) exposure (OR=1.17, 95%CI: 1.10-1.24), so was with phthalate (PAEs)and (OR=1.11, 95%CI: 1.05-1.11)Bisphenol A(BPA) (OR=1.25, 95%CI: 1.03-1.50). BPA exposure concentration had no correlations with sex, TC, or LDL, but had them with WC, HDL, age and BMI (SMA=0.16; 95%CI=0.08-0.23; SMD=-0.19; 95%CI:-0.27- -0.12; SMD=-0.78; 95%CI:-1.42- -0.14;SMD=0.08; 95%CI: 0.00-0.16).
Conclusions: EEDs exposure is a risk factor for CVD. Long-term exposure to EEDs can influence cardiovascular health in human, and the synergistic effect between homologs is significant, which may affect the outcome. In the investigations on the influencing factors of CVD exposed to BPA, the exposure concentration has no correlations with sex, TC or LDL, but has them with WC, HDL, age and BMI. The mechanism still needs to be to explored and demonstrated by many prospective cohort studies, in vitro/in vivo results, as well as indices affecting CVD.

Key Words: Environmental endocrine disruptor,Cardiovascular diseases Meta analysis,Systematic review
 

Biography:

Xiangjun Fu：Female, master, research direction is environmental toxicology.