Title: PREDICTORS OF TREATMENT OUTCOME AMONG DRUG RESISTANT TUBERCULOSIS PATIENT AT THE OUTPATIENT TB DOTS FACILITY OF ZAMBOANGA CITY MEDICAL CENTER

Abstract:

The Philippines is one of the high tuberculosis burden countries and drug- resistance is widespread in the country and abroad and threatens the success of TB program. Timely and efficient MDRTD treatment is crucial in preventing disease transmission and reducing the morbidity and mortality. Review of literature showed disparate predictors of treatment outcome and only prevalence studies are available in the Philippines. Hence, the findings of this study can be different among Filipinos. This study aims to determine the predictors of treatment outcomes among drug-resistant patients in outpatient setting at Zamboanga City Medical Center TB DOTS Center to enhance the TB program and its outcome.
This study is a retrospective cohort analytical design, which was conducted at the TB DOTS Center of Zamboanga City Medical Center. Using the data registry book from January 2015 to December 2019, patient’s demographic, and clinical characteristics were reviewed, collected, tabulated and analysis was done using binary regression to determine the predictors of treatment outcomes among drug-resistant tuberculosis patients. Of the 207 DR-TB patients, only 176 were included in the analysis, 120 (68.2%) had successful treatment outcome while 56 (31.8%) had poor treatment outcome. Age less than 40 years (p value= 0.038), absence of diabetes (p value= 0.079) and susceptible to isoniazid (p value= 0.025) and streptomycin (p values=0.012) were predictors of good outcome while none of the variables were predictors of mortality. The common drug resistance pattern were Rifampicin-resistant (56.8%), followed by MDR TB (36.4%).
The common characteristics of drug-resistant tuberculosis are male sex, age more than 40 years old, married, living in urban areas and with history of previous TB treatment. None of the variables were predictors of mortality however, age less than 40 years old, absence of diabetes, TB strains susceptible to isoniazid and streptomycin were predictors of good outcome.
Drug resistant, treatment outcomes, MDR-TB, treatment success, poor outcomes MESH WORDS
 

Biography:

Dr. Lester Jay Corsame finished his residency training in Internal Medicine at Zamboanga City Medical Center. He received his diplomate degree in 2022. Currently, he is under deployment program of the Department of Health to the rural areas.