Title: Basis of Novel Therapeutic approaches for Cardiovascular Disease
Abstract:
Statement of the Problem: Cardiovascular Disease remains the major killer in the Western world despite the demonstrated benefits of lipid lowering therapies. Novel approaches are being investigated to address further therapeutic needs, currently with limited success. Processes leading to heart attacks include lipid deposition (i.e. cholesterol), lesion progression and recruitment of immune cells with their activation, subsequent plaque rupture and release of prothrombotic components. Ultimately, blockage of blood flow occurs. Of the pathways involved, two major mechanistic pathways have been under study: 1). elevation of HDL, by any means, to enhance cholesterol efflux and removal of cholesterol from the vascular wall to drive the process of reverse cholesterol transport (RCT). This is movement of cholesterol from cells of the atherosclerotic vasculature to HDL in the blood and subsequently to the liver for modification and excretion to the gut for elimination from the body, and 2). regulation of inflammatory pathways in attempts to inhibit vessel wall plaque degradation and rupture leading to heart attacks.
Epidemiologic studies have shown significant correlations of HDLc levels with reduced cardiovascular events. A number of methods for elevating HDL have been under study, among which a significant focus has been to inhibit the activity of cholesterol ester transfer protein (CETP). CETP is an enzyme that transfers cholesterol ester from HDL to LDL. Blocking this enzyme leads to elevations of HDL cholesterol and increases in HDL particle size. Though this approach has successfully enhanced cellular cholesterol efflux, the first step in RCT, numerous attempts in the clinic have failed to show benefit in reducing cardiovascular events. Recent findings have suggested that subsequent function of the HDL particles may be affected in a negative way, with activities of HDL modifying enzymes reduced as well as uptake by hepatic cells. Thus, although initially seemingly successful in enhancing efflux, cardiovascular events were not reduced. A number of additional / novel approaches to HDL modulation are now under study.
A second approach currently under investigation is regulation of clinical events through inhibition of inflammation in the vascular wall. With the initiation of atherosclerosis, lipid is deposited and immune cells including macrophages are recruited to the site. As lesions develop, cells become engorged with lipid, becoming foam cells, and through during these processes, become activated. Activation enhances cell recruitment and release of cytokines and expression of adhesion molecules. Proteolytic enzymes are also released, with breakdown of the intimal surface and of vulnerable regions of the lesion cap, resulting rupturing of the plaque. Pro-thrombotic contents of the vessel wall are then released, leading to blockage of the lumen of the vessel, and of blood flow. Inhibition of immune cell recruitment and activation are an important approach to therapeutic treatment of cardiovascular disease, with some success established, but significant improvements to the approaches needed. Innovative methods to effect this process will be discussed.
Conclusion: Several novel therapeutic approaches to treatment of cardiovascular disease are under study, but improvements to achieve therapeutic benefit will be required.
Biography:
Steven J. Adelman, Founder and CEO of Vascular Strategies LLC, and CSO, NanoPhagix LLC has more than 25 years’ experience in drug discovery and development. Previously led several initiatives at Wyeth Pharmaceuticals: Senior Director, Cardiovascular and Metabolic Disease Research and Senior Director, Atherosclerosis CV/Women’s Health. Activities included identifying and validating discovery and development programs (small molecules and biologics), advancing more than 10 compounds through IND into clinical development. Expertise includes atherosclerosis and CVD, inflammation, immune biology, and women’s health. Worked extensively on rapamycin (sirolimus, Rapamune) for transplant indications and subsequent incorporation on the Cypher-stent, first successful drug-eluting coronary stent. Honors and memberships include elected Fellow American Heart Association; Golden Heart Member, Council on Arteriosclerosis, Thrombosis and Vascular Biology, Basic Sciences Council, Functional Genomics and Translational Biology Interdisciplinary Working Group, AHA, and International Atherosclerosis Society. Authored more than 100 articles and abstracts and holds over 30 patents.
Title: New approach to hyponatremia yields high prevalence and identification of natriuretic protein that causes renal salt wasting and strategies to reduce fluid overload in heart failure
Abstract:
John K Maesaka was born in Hawaii, received degrees from Harvard College and Boston University School of Medicine, did his medical residencies at BarnesJewish Hospital at Washington University In St. Louis and Mount Sinai Hospital in New York and renal fellowship at Mount Sinai Hospital. His interest-driven decision to spend 5 years exclusively in the renal physiology laboratory at Mount Sinai Hospital as a renal fellow and member of the faculty proved to be the best investment he made to pursue an academic career in medicine. He was involved in developing colorimetric methods for the determination of uric acid and phosphorus in blood and urine that were applied to studying the transport characteristics of both electrolytes by renal micropuncture techniques in rat kidney. He developed several bioassays to demonstrate the presence of a natriuretic factor in the blood of patients with renal salt wasting and Alzheimer’s disease and more recently identified the elusive natriuretic factor after more than a 25-year pursuit.
Biography:
John K Maesaka was born in Hawaii, received degrees from Harvard College and Boston University School of Medicine, did his medical residencies at BarnesJewish Hospital at Washington University In St. Louis and Mount Sinai Hospital in New York and renal fellowship at Mount Sinai Hospital. His interest-driven decision to spend 5 years exclusively in the renal physiology laboratory at Mount Sinai Hospital as a renal fellow and member of the faculty proved to be the best investment he made to pursue an academic career in medicine. He was involved in developing colorimetric methods for the determination of uric acid and phosphorus in blood and urine that were applied to studying the transport characteristics of both electrolytes by renal micropuncture techniques in rat kidney. He developed several bioassays to demonstrate the presence of a natriuretic factor in the blood of patients with renal salt wasting and Alzheimer’s disease and more recently identified the elusive natriuretic factor after more than a 25-year pursuit.
Title: Nutraceuticals in the prevention and treatment of atherosclerosis and cardiovascular disease
Abstract:
Atherosclerosis, an inflammatory disorder of medium and large arteries and the underlying cause of myocardial infarction and cerebrovascular accidents, is responsible for more global deaths than any other disease. Although reduction in mortality from atherosclerosis and its complications has been achieved recently by lifestyle changes and pharmaceutical intervention, this is expected to reverse in the future because of global increase in risk factors such as hypercholesterolemia, obesity, and diabetes. Current pharmaceutical therapies against atherosclerosis are associated with substantial residual risk for cardiovascular disease together with other issues such as side effects. In addition, pharmaceutical agents against many promising targets have proved disappointing at the clinical level. It is therefore essential that the molecular basis of atherosclerosis is fully understood, and new therapeutic/preventative agents or targets are identified and validated.
The major focus of recent research in my laboratory is to understand the molecular mechanisms underlying the protective anti-atherogenic actions of natural products using a combination of in vitro and in vivo model systems together with biochemical, molecular biology and immunological approaches. Our research has provided novel insights into the mechanisms underlying the protective actions of several nutraceuticals. This presentation will discuss the molecular basis of atherosclerosis and opportunities for drug discovery, current therapies against the disease and their limitations, emerging therapies targeting lipid metabolism and the inflammatory response, new challenges, and the potential of natural products as preventative and therapeutic agents with focus on probiotic bacteria.
Biography:
Dipak Ramji is Professor of Cardiovascular Science and Deputy Head at the School of Biosciences in Cardiff University. He is also Fellow of the Learned Society of Wales. He received his BSc (Hons) degree (Biochemistry) and his PhD (Molecular Biology) from the University of Leeds. This was followed by post-doctoral research at EMBL (Heidelberg) and IRBM (Rome) with fellowships from the Royal Society and the EU. His current research is focused on understanding how natural products regulate cellular processes in heart disease with the goal of attaining deeper mechanistic insight and identifying preventative/therapeutic agents. He has published over 150 research articles (h index 41 and i10 index 76 with over 8350 citations), including 880-page book in 2022 on Methods in Atherosclerosis. He is an Editorial Board member of 16 international journals; regular organising committee member, speaker, and track/session chair at international conferences on heart disease; involved in grant evaluation for over 20 organisations; and supervised over 25 PhD students
Title: An Investigation of Left Ventricular Valve Disorders and the Mechano-Electric Feedback Using a Synergistic Lumped Parameter Cardiovascular Numerical Model
Biography:
Eun-jin Kim is a Professor in Physics and Applied Mathematics at Coventry University, UK. She obtained her PhD in Physics from the University of Chicago, USA. She held postdoctoral positions at the Universities of Leeds/Exeter in UK, High-Altitude Observatory in Boulder, USA and University of California, San Diego, USA, and Assistant and Associate Professor positions at the University of Sheffield, UK. She is interested in self-organisation and complex systems/non-equilibrium processes including cardiac dynamics. She was awarded the Leverhulme Trust Research Fellowship and published over 130 refereed journal papers.
Title: A web-based prehabilitation program for on-table extubation after minimally invasive transaxillary mitral valve surgery
Title: Effects of periodized training regime on vascular and autonomic systems in patients with coronary artery disease: a pilot randomized controlled trial
Title: A Proposed Approach for the Management of Diastolic Dysfunction: Optimization of the E and A Wave Measurement, Morphology and Timing
Abstract:
Much focus over the past few decades has been on the systolic phase of the cardiac cycle, yet it is becoming evident that more advanced therapies are warranted for the clinical management of heart failure, specifically diastolic dysfunction. A novel optimized approach in evaluating and managing diastolic dysfunction/ heart failure is required to evaluate and treat cardiac dysfunction. The proposed measures include the evaluation of the baseline functionality of the cardiac conduction system, Baseline E and A wave Measurement and Morphology (BEAMM) and STRess-induced E and A wave Measurement and Morphology (STREAMM) with timing and variability taking into consideration of both macro and micro diastolic myocardial processes. Implementation of a management plan that includes echocardiographic optimization (ECHO-Op) and pharmaceutical optimization (PharmOp) into the current guideline recommendations for the evaluation and management of diastolic dysfunction/ heart failure is an additional goal. Clinical adoption of the proposed approach may lead to earlier identification of patients at risk of diastolic dysfunction/ heart failure as well as other associated cardiac symptoms and downstream pathological processes.
Biography:
John R. Dylewski, MD, FHRS, FACPAS is a cardiac electro physiologist and professor of medicine in active clinical practice for the last 20+ years with an extensive and diversified background in materials engineering and medical applications of artificial intelligence to improve healthcare delivery. With the abundance of valuable data generated for patient care and the continuous production of scientific knowledge, Dr. Dylewski found it significantly challenging to deliver accurate, up-to-date and expeditious care to his tens of thousands of patients resulting in the development of the Complaint2Care model for a novel healthcare delivery platform, LifeSaver, powered by Apollo Artificial Intelligence.
Title: Pasteurella Multocida: A Case Report on the Presentation and Challenges of Cellulitis, Osteomyelitis and Myocarditis
Biography:
Pooja Patel completed her medical school in Mumbai, India and is currently pursuing her Internal Medicine residency at Larkin Community Hospital in South Miami, Florida. She is currently a PGY2 resident, who aspires to specialize in cardiology and critical care. She is from the Midwest, not fearing living in the oh-so-cold winters. Patel enjoys learning and improving her skills, in every aspect available. She believes ‘teaching others is the easy way to learning’. Patel also completed and received her Master’s in Biomedical Sciences. She has volunteered her time at a non-profit organization since 2017, at Waukesha Free Clinic in Waukesha, Wisconsin (former St. Joseph’s Medical Clinic), and still continues to do so whenever possible. Patel was awarded the Director’s Coin during her rotation at the VA Medical Center in Grand Junction, Colorado for the care provided to our veterans, and for volunteering to help the community in times of the COVID surge in the late 2021. As a physician, she prides herself on serving those who have served our country.
Title: Spontaneous Coronary Artery Dissection in the Brazilian Scalibur Registry. Insights from Demographic and Angiographic Characteristics of 219 Patients
Abstract:
Background: Over the last decade, there has been a new understanding of spontaneous coronary artery dissection (SCAD) mainly due to data derived from registries in the United States and Europe. Findings from other ethnicities including Latin America are not well known.
Methods: In the Scalibur Brazilian registry, a retrospective and prospective data from 22 Hospitals were collected regarding clinical presentation, and angiographic characteristics.
Results: 219 patients with SCAD (85% women, mean age 50.15±10.56 years) were included; patients had none or few traditional risk factors for coronary artery disease (Table). Identifiable triggering factors (present in 57.8% of cases) included emotional stress (21%) physical stress (5.42%), and vasoconstrictor substance-use (1.20%). Most patients presented as non-ST elevation myocardial infarction (non-STEMI) following by ST elevation myocardial infarction (STEMI) and unstable angina. Fibromuscular dysplasia, not systematically screened, was found in few cases (4.21%). Left anterior descending artery was most frequently affected (57%), and approximately one fifth of patients had multiple coronary territories involvement. SCAD classification of type II, followed by type I were the most common angiographic findings. Cardiogenic shock on admission was present in 3% of cases, affecting most (50%) patients in the pregnancy-associated period. Yet, 73.49% of patients were managed medically, 21% had percutaneous coronary intervention and 0.6% had coronary artery bypass grafting (Table).
Conclusion: In this large Brazilian cohort, SCAD affected mostly young women with none or few classical risk factors for coronary artery disease. Demographic, clinical, and angiographic findings seem to be similar to other ethnicities. This condition should be considered as a differential diagnosis in acute coronary syndrome, especially in young women (< 50 years).
Biography:
Performance driven professional over 16 years of clinical expertise as cardiologist and heart failure specialist gained from esteemed positions at the top hospitals in Sao Paulo. Robust and current knowledge of scientific, clinical, regulatory, commercial, and competitive landscape in applicable therapeutic area. Demonstrated leadership skills in managing time and overseeing projects. Exhibited attention to detail and utilized public speaking and written communication skills to convey information effectively. Resolved complex problems, showcasing analytical thinking and problem-solving abilities. Cultivated solid and positive relationships with team members, fostering collaboration. A stimulated and organizational physician in search of constant learning, passionate about technology and innovation, and committed to enhance health education and mentoring.
Title: Immunological predictors of myocardial injury development after coronary artery stenting
Abstract:
More than three million myocardial revascularization procedures are performed annually in the world. Recently, the ratio of angioplasty with coronary artery stenting and coronary artery bypass grafting in Europe is 2:1, in the USA and Japan – 6:1. Small myocardial injuries occur in 8-15 percent of cases after planned intracoronary stenting. It is often manifested only by the level of increase in cardiospepific immunological markers of myocardial damage without clinical and electrocardiographic signs of myocardial damage. The results of studies of 100 patients with coronary artery disease and stable angina (the second and third functional class) in one day after percutaneous coronary intervention with implantation of intracoronary stents (Xience, Taxus, Cypher, Vision, Kaname) in the department of the Federal Center for Cardiovascular Surgery during one year of follow-up were studied. Study group: patients on the first day after intracoronary stenting without clinical manifestations and changes in electrocardiography, but with immunochemical manifestations of small myocardial injury syndrome. Comparison Group: patients on the first day after intracoronary stenting without complications. Control group: 30 patients before intracoronary stenting. In the blood of patients of the studied groups, the levels of MB-creatine phosphokinase and troponin T were determined in dynamics by electrochemiluminescence using Elecsys reagent kits from Roche on the Elecsys2010 immunochemical analyzer from Roche Diagnostics (Switzerland). As a result of the conducted studies, some immunological and clinical-instrumental predictors of the risk of developing small myocardial injury syndrome after intracoronary stenting were established in patients with coronary artery disease and stable angina of the second functional class and the third functional class: diffuse coronary artery lesion (p<0,001), stenosis length – 24,07±1,3 mm (p<0,001), recanalization and stenting of coronary arteries (p<0,05), lateral branch occlusion (p<0,05), implantation of metal stents (p<0,05), implantation of two or more stents (p<0,05), the level of blood leukocytes – 10,23*10^9 / l (p<0,05), systemic atherosclerosis (p<0,05). Small myocardial injuries have an adverse effect on the long-term results of intracoronary stenting in patients with coronary artery disease and stable angina of the second functional class and the third functional class even after one year of follow-up after surgery: return of angina (2,86%), repeated hospitalizations (5,71%).
Biography:
In 2005 has completed her PhD at the at the National Medical Research Center of Cardiovascular Surgery. Head of the Department of Cardiology of the State Medical University from 2008 to 2018, then professor of this Department. Head of the Primary Vascular Center for the Treatment of Patients with Acute Coronary Syndrome and Acute Stroke from 2013 to 2018. Since 2018 has been a professor at the Department of Cardiology of the Central Medical Academy of the Presidential Administration of RF. She is the chief physician of the Cardiological Center. She is the author of 12 Patents for innovations, 3 monographs, 12 educational tutorial. Awarded a Silver and a Bronze Diploma of the International Championship (International Academy of Sciences and Higher Education, London, UK, 2012). She has published over 300 articles, has been serving as an of 5 editorial boards member.
Title: Effects of periodized training regime on vascular and autonomic systems in patients with coronary artery disease: a pilot randomized controlled trial
Abstract:
Background: Periodized exercise training regime in clinical populations have not been well studied until currently days. The purpose of this study was to compare the effects of a periodized training regime to a non-periodized training regime in cardiorespiratory fitness (CRF), heart rate variability (HRV) and pulse wave velocity (PWV) parameters.
Methods: Twenty-four trained patients with stable coronary artery disease (CAD) (64±10 years) were randomized in 2 groups: linear periodized combined exercise training (LPCET) and non-periodized combined exercise training (NPCET) which performed 60 exercise training sessions (3 times per week) for 6 months. Baseline and end-protocol evaluations included: 1) incremental symptom-limited cycling cardiopulmonary exercise test; 2) one-repetition maximum; 3) arterial stiffness; and 4) heart rate variability.
Results: neither of the 2 groups increased VO2 peak nor overall strength (p>0.05). The LPCET group increased 22% in Central pulse pressure (p=0.04); decreased 16% in upper limb PWV (p=0.009); 7% in Central diastolic blood pressure (p=0.05) and 11% in left ventricular ejection time (LVET) (p=0.05). The NPCET group decreased significantly 10% in upper Limb PWV (p=0.049), 9% in lower limb PWV and 16% in LVET (p=0.015). There were no significant differences between pre-post training in HRV index in both groups. Moderate Pearson´s correlation was found in LPCET: VO2peak-Aortic PWV and SDNN-Aortic PWV (p<0.05; r=-0.4; r=-0.3 respectively).
Conclusion: Long-term non-periodized training regime in stable CAD patients was more effective to improve peripheral arterial stiffness than the periodized training regime. Both training models were equally effective in maintaining the HRV index. The current study suggests that exercise training may improve arterial stiffness but not autonomic balance independently of exercise type training prescription in trained CAD patients. More studies have to be performed to understand the PWV-HRV and the effects of new training approaches.
Future directions: A gap may exist in exercise protocols when the daily physiological individuality is not considered. As HRV as daily physiological state, both are constant variable. The most appropriate stimulus may be the one that respects the direct and indirect conditions of the organism. Correlating self-perception (i.e. Brums and Borg scale) and physiological variables may be an alternative to enhance the improvement of health and performance.
Biography:
Graduated in Physical Education from the Regional University of Blumenau Foundation (2007); Postgraduate courses related to special groups and biomechanics between 2009-2011 at the Gama Filho University. Postgraduate with emphasis on the improvement in cardiovascular rehabilitation at the Instituto do Coração; Master in Human Movement Sciences from the State University of Santa Catarina (2013). University Teacher (2010-2015) at FURB institutions; UNIDAVI; UNIFEBE; UNIASSELVI; UNIMAX (current job 2022) (Biochemistry of Exercise; Resistance Training; Biomechanics & Kinesiology; Technology in Physical Education). Ph.D scholarship by CNPQ “Ciências Sem Fronteiras” program (Faculty of Human Motricity, 2015-19); Responsible for the teaching/research/extension process at the Cardiovascular Rehabilitation Center of the University of Lisbon (CRECUL). Dissertation/Thesis theme: Acute Responses and Chronic Effects of Autonomic/Cardiovascular/Cardiopulmonary Systems following exercise training. Research and professional activities in the area of health, training, cardiology, exercise biochemistry, musculoskeletal rehabilitation, cardiovascular rehabilitation, stress, nervous system and vascular system.
Title: Conduction abnormalities after TAVI
Abstract:
Transcatheter aortic valve implantation is a procedure that allows the aortic valve replacement via minimally invasive technique. We can distinguish several access methods: transfemoral, transapical, subclavian, direct aortic as well as transcaval. Patients who underwent TAVI have a lower mortality rate in comparison with those who have non-operated severe aortic stenosis. Although advantages prevail over disadvantages, the procedure may entail conduction abnormalities. The most common are: left bundle branch block and high-grade atrioventricular block. The proximity of the aortic valve to the conduction pathways (possible injury as a result from interventional equipment interactions) as well as the anatomical variants of AV nodes may predispose patients who underwent TAVI to higher risk of conduction abnormalities. We can distinguish several factors that have the evident impact on previously described complications, such as: pre-existing RBBB, type of the transcatheter valve, annular size, depth of the implantation and the degree of mitral and aortic valve calcifications. The electrocardiographic recordings that are the cause of concern are narrow QRS complexes (especially before TAVI) as well as fluctuating changes in PR interval. Among risk factors for LBBB development we can underline the self-expandable prostheses (in comparison with balloon-expandable ones) and larger implant depth. The behavior of heart blocks has been noticed to change dynamically during and after aortic valve replacement. Patients who presented conduction abnormalities before TAVI, were in the higher risk group. Majority of the heart blocks are reversible. The management of conduction abnormalities after transcatheter aortic valve implantation is based on the clinical status of our patient and ECG monitoring. Temporary pacemakers and PPM are being implanted if needed.
Biography:
Stefania Czapp has graduated from Medical University of GdaĆsk in 2021 and now she is doing her postgraduation internship in Szpital Morski im. PCK in Gdynia (Poland). She has the big interest in Cardiosurgery and is planning to do her PhD in this field of science in Poland.
Title: Angiotensin converting enzyme gene D-allele, a possible risk factor for procedural complications in the coronary artery disease patients
Biography:
Hossein Sarmast graduated in general medicine (GP) then He began to general surgery residency in 2013 at Damascus university and graduated as a general surgeon (GS) in 2016. After that He began to cardiovascular surgery residency in 2017 and now , He is the last year cardiovascular surgery resident at Damascus university (2019).
Title: Cardiovascular Complications of COVID-19 among Pregnant Women and Their Fetuses: A Systematic Review
Title: Challenges in Cardioncology: Aortic Dissection after Cancer Treatment with Angiogenesis Inhibitors
Biography:
Ahmed N Ghanem was qualified in 1968, Mansoura University, Egypt. He gained all postgraduate experience in UK where he was promoted in posts up to the consultant level. He practiced as consultant Urologist in UK, Saudi Arabia and Egypt. During his career life he reported over 60 articles of which he made important discoveries in medicine, physiology, urology, nephrology, cardiovascular and surgery. He discovered two new types of vascular shocks, proved that one physiological law is wrong and provided an alternative. He resolved the puzzles of 3 clinical syndromes; the transurethral of the prostate (TURP) syndrome, the loin pain hematuria syndrome (LPHS) and the adult respiratory distress syndrome (ARDS). He is now on the editorial board of many medical and surgical journals and he is happily retired in Egypt.
Title: Opening pulmonary valve in patients of heart failure
Abstract:
Introduction: The patients’ assessment of the care navigating cardiovascular disorders is imperative to improving the quality of care provided. The purpose of this study was to explore the perspectives of people living with cardiovascular disorders on the care they received and its relationship with general self-efficacy. Methods: This investigation employed a cross-sectional correlational approach. The study sample was comprised of patients with cardiovascular disorders from both the King Khalid University and the King Salman Specialist hospitals, Hail City, Saudi Arabia. Convenience sampling was used, resulting in 104 participants. A survey using a self-administered questionnaire was employed to collect the data, which was collected from March 10 through May 20, 2023. Results: The participants perceived that they have occasionally (2.67/5) received care, and they perceived themselves to have better self-efficacy (25.28/40). Of note, the age (0.062), years of being diagnosed with having the disease (-0.174), sex (0.180), educational attainment (0.125), and occupation (0.206) were found to have no significant relationship with the patient assessment of care with chronic cardiovascular (PACIC). However, civil status (0.867) was found to have a strong positive correlation to the PACIC. No significant relationship was found between age (0.070), civil status (0.013), years being diagnosed with having the disease (0.095), educational attainment (0.088) or occupation (0.115). However, sex (0.795) was found to have a strong correlation with the general self-efficacy (GSE). Finally, there was a strong correlation between the GSE and the PACIC (0.881). Conclusion: The PACIC and the GSE had a strong association with one another. This study illuminates the value of self-efficacy and patient involvement as self-management techniques for cardiovascular illnesses. Future cardiovascular illness self-management initiatives should concentrate on enhancing patient self-efficacy by adopting the PACIC.
Biography:
Aida Sanad Alqarni, RN & PhD of nursing. Dean college of Nursing Abha at King Khalid University (KKU) my responsibility as academic work experience, Assistant Professor. Degree obtained: Doctor of Philosophy in Critical Care Adult Nursing (PhD), University of Adelaide (UOA), South Australia (2012-2018), Master of Nursing Science, UOA, 2011-2012. RESPONSIBILITIES WITHIN THE COLLEGE OF NURSING AT KING KHALID UNIVERSITY: Heading the Faculty Council and supervision on organizing its affairs. Achieving the aims and the higher policies in King Khalid University. Supervising on preparing the strategic plan of the faculty and monitoring its execution. Supervising the management of the educational, research, administrative, and financial affairs of the Faculty. Evaluating the performance of the Faculty deputies and the Academic departments’ heads and the Managers of the affiliated units. Nursing lecturer: Deliver teaching material using appropriate teaching, learning support and assessment methods. Supervise students undertaking project work.Collaborate on course development and curriculum changes.Provide contribution to community service on behalf of the College.Conduct research projects. OTHER EMPLOYMENT RELEVANT TO THE NURSING PROFESSION: Perform routine tasks as ICU, Burn Unit & Obstetric ICU Nurse.