Title: Development and characterization of solid dispersion-based orodispersible tablets of Theophylline

Abstract:

The goal of the current study is to improve the solubility of medications that are poorly water soluble by using the lyophilization process. Theophylline is a bronchodilator that belongs to the Xanthene class. It is used to treat lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). The experimental work first studies the saturation solubility of drugs in water, salivary amylase, and 6.8 buffer solutions. Theophylline is lyophilized in the study using solubility-improving polymers such as polyvinyl pyrrolidone (PVP K30) and β-cyclodextrin as well as excipients. The study also focuses on the formulation and development of orodispersible tablet dosage forms of theophylline by the lyophilization method. The saturation solubility study of a pure drug (8.3 mg/mL) is compared with the solubility of a lyophilized product (21 mg/mL) of a drug. It is found that the lyophilized product has greater solubility than the pure drug, which is crystalline in nature. A dissolution analysis of orodispersible dosage forms was also conducted in the study, which showed 90.21 % CDR for orodispersible tablets in 15 min.

Biography:

Prashant J. Shinde is recently working as assistant professor at Department of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar, Maharashtra, India. He has post graduated from pharmaceutics stream in 2019. He has published several research, review papers and book chapters at national and international level and participated in various national and international conferences and workshops. He has 3 years of experience in academics and research. He has guided 13 students for project and research work in his academic career. During his tenure he served as an academic committee member in his institution and university. He worked with accreditation compliance/self-study projects at the university and college level. He is active member of Indian pharmaceutical association and Maharashtra state pharmacy council. He is a volunteer and member of UNICEF- INDIA and participated in different social progress activities of rural development.