Pharmacotherapy has been related with undesirable health consequences such as adverse effects, interactions, adherence problems, functional decline, cognitive problems, falls, urinary incontinence and Metabolic or nutritional problems6,7,8,9,10,11,12,13. The risk of these problems increases with the number of drugs. Polypharmacy, defined as the use of more than four or five drugs, occurs in 40% of the adults over 65 years old. Drug regulation is a process by which we can control the use of drug by international agreement and through some regulatory authorities like US Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the Japanese Pharmaceutical and Medical Devices Agency (PMDA).