Title: Stability of perindopril – important representative of angiotensin converting enzyme inhibitors

Abstract:

Despite of the existence of many prevention programs, cardiovascular diseases remain a leading health problem in developed countries. The global reach of hypertension is constantly growing, it is estimated that in 2025 the number of hypertension patients will reach 1.5 billion. That means that every fifth person in the world has increased blood pressure, and every third in developed countries [1]. Due to such a wide perspective of the use of antihypertensive medicines, it is highly desirable to expand knowledge of used drugs used. A chemically stable molecule is one of the parameters that gives the drug the highest quality. For this reason, the stability of a drug in a solid phase is an extremely important step in the development of research on pharmacologically active compounds. Previous research work on the stability of angiotensin converting enzyme inhibitors (ACE-I)  has shown that compounds in this group are unstable, easily degrade under conditions of increased temperature and humidity [2-7].