Title: Correlation of clinical and laboratory aspects with the MT1A rs8052394 gene associated with metabolic syndrome in patients with hypertension.

Abstract:

The MT1A gene (Metallothionein 1A) is genomically located 16q13. Metallothioneins play a role in the metabolism of zinc and copper and may be involved in neutralized free radicals in protecting against reactive oxygen species. The rs8052394 polymorphism is associated with DM2, MS, OB, insulin resistance. The aim of the study is to test the association of the MT1A gene with MS in patients with hypertension based on clinical data, laboratory investigations and genetic methods. The study was performed on 37 subjects from hospital Giurgiu, 34 with hypertension and 3controls, based on clinical data: BMI, hypertension, sex and age, biochemical laboratory investigations: glucose, triglycerides, cholesterol, HDL, LDL, uric acid, magnesium, Hba1c performed on the BS300. The MT1A rs80523994 gene is sequenced by the Advenced NGx test. The results were processed by Graph Pad Prism 7.0.3, MDR 3.0.2 and Matlab R2009b for artificial neural networks. It turns out that the genotype rs 8052394 has predominantly the genotypes of 20 homozygous and 9 heterozygous and 8 recessive who showed high levels of glucose and HbA1c concentrations are associated with cardiovascular disease, diabetes and obesity, which may increase the risk of MS.

Biography:

Stanislav Alexandra Alina has completed his PhD at the age of 30 from the Department of Genetics, Faculty of Biology, University of Bucharest. It has studied classical and modern methods of human genetics, biochemical and hematological laboratory investigations, clinical aspects, risk factors and bioinformatics methods. The dissertation was performed on the Department of Epigenetics studying Alzheimer's Disease and the genes associated with it and the license was performed at the Department of Microbiology of the same faculty studying Staphylococcus aureus.