Use of anti-inflammatory reliever therapies to reduce asthma exacerbations

2024-11-13 - 2024-11

Use of inhalers containing both a fast-acting bronchodilator and anti-inflammatory inhaled corticosteroids (ICS) for relief of symptoms has reduced the rate of asthma exacerbations compared with short-acting beta-agonists (SABA) alone in several randomized trials of adolescents and adults. In a new network meta-analysis, compared with SABA alone, severe asthma exacerbations were significantly reduced for both ICS-formoterol (13 trials, 19,184 patients; risk difference 10.3 percent, risk ratio [RR] 0.65) and ICS-SABA (4 trials, 4852 patients; risk difference 4.7 percent, RR 0.84) [1]. Our authors recommend these anti-inflammatory reliever therapies for those with variable asthma symptoms or frequent exacerbations and prefer them for all patients with asthma.

High diagnostic uncertainty in community-acquired pneumonia

2024-10-11 - 2024-10

Because community-acquired pneumonia (CAP) is common and its symptoms overlap with many other cardiopulmonary disorders, it is both over- and underdiagnosed on presentation. In a recent study of over two million hospitalizations in the US Veterans Administration health system, 36 percent of over 215,000 patients with an initial emergency department (ED) diagnosis of pneumonia did not carry this diagnosis upon hospital discharge, and 33 percent of over 239,000 patients discharged with a diagnosis of pneumonia and positive initial chest imaging lacked an ED diagnosis [29]. These findings reinforce the importance of assessing patients initially diagnosed with CAP for alternative processes and being open to the possibility of CAP in patients initially diagnosed with other conditions.

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Use of anti-inflammatory reliever therapies to reduce asthma exacerbations

High diagnostic uncertainty in community-acquired pneumonia

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Use of anti-inflammatory reliever therapies to reduce asthma exacerbations

High diagnostic uncertainty in community-acquired pneumonia