Title: The prevalence of Heart Failure in patients with Chronic Obstructive Pulmonary Disease: A systematic review and meta-analysis

Abstract:

Background: To assess the prevalence of heart failure in patients with COPD.

Methods: CENTRAL, Embase, and MEDLINE were searched for studies from 2017 up to June 2022 using the medical subject headings “COPD” and “Heart failure”. The risk of bias was assessed using the Newcastle-Ottawa scale for observational studies. The studies were narratively and statistically analyzed. Studies were reviewed in accordance with PRISMA guidelines.

Results: Of 3346 studies identified, 2220 were screened for title and abstract, and 348 were selected for full-text review. 11 studies were eligible for inclusion involving 91,919 participants, of which 10 were included in our meta-analyses. 3 conditions were investigated (i.e., HF, LVDD, and RVDD), of which 2 conditions were included in the meta-analyses and all were descriptively synthesized). From our meta-analyses, we found overall pooled prevalence estimated of was 16 %, 95 % CI (12 % to 19 %), for heart failure; and 61 %, 95 % CI (53 % to 70 %), for LVDD. The pooled data for HF were significantly heterogenous (I2= 97.55 %, p<0.001), whereas the pooled data for LVDD were moderately heterogeneous (I2= 50 %, p= 0.16). Discussion: Meta-analyses for LVDD and HF had a moderate to large statistical heterogeneity. Only three studies out of 11 aimed to investigate the primary outcome of HF or LVDD. HF is a clinically important condition that is prevalent within a significant proportion of patients with COPD and negatively impacts important clinical outcomes. There is a need for more research investigating HF prevalence in COPD. In addition, we hope this review raises the awareness of clinicians and policymakers to consider implementing diagnostic tools to assess HF among the COPD population. 

Other: This systematic review is registered with PROSPERO, CRD42022328570

Biography:

Sufana is a Lecturer in the Respiratory Care Department at Imam Abdulrahman bin Faisal University, Saudi Arabia. Master of Respiratory Medicine from the University of Birmingham, UK. Bachelor of Respiratory Care from AlMaarefa University, Saudi Arabia.