Scientists discover a new mechanism to generate cartilage cells

2022-12-09 - 2022-12

Cartilage degeneration and injuries affect 350 million people worldwide. Patients with these conditions experience increased pain and discomfort over time. However, an exciting breakthrough in tissue regeneration research offers the promise of meaningful relief. The study, led by faculty at The Forsyth Institute, suggests a new approach for making cartilage cells with huge implications in regenerative medicine for future cartilage injuries and degeneration treatments.

Ancient disease has potential to regenerate livers

2022-12-09 - 2022-12

Leprosy is one of the world's oldest and most persistent diseases but the bacteria that cause it may also have the surprising ability to grow and regenerate a vital organ.

Cancer stem cells are fueled through dialogue with their environments

2022-12-09 - 2022-12

What drives tumor growth? Is it a few rogue cells imposing their will upon healthy tissue, or diseased tissue bringing out the worst in otherwise peaceable cells? Or is it a back-and-forth, a dialogue between the two? According to a new study, it may be the latter, at least when it comes to the progression of one common skin cancer.

A high-fat diet in pregnant monkeys impairs fetal blood stem cells

2022-12-09 - 2022-12

Maternal consumption of a Western-style diet alters the transcriptional landscape of fetal blood stem cells in rhesus macaques, researchers report November 3rd in the journal Stem Cell Reports.

A look inside stem cells helps create personalized regenerative medicine

2023-05-23 - 2023-05

Organelles -- the bits and pieces of RNA and protein within a cell -- play important roles in human health and disease, such as maintaining homeostasis, regulating growth and aging, and generating energy. Organelle diversity in cells not only exists between cell types but also individual cells. Studying these differences helps researchers better understand cell function, leading to improved therapeutics to treat various diseases.

Gamma delta T cells can fight aggressive breast cancer

2023-05-23 - 2023-05

Triple-negative breast cancer (TNBC) is the most aggressive and deadly form of breast cancer with limited treatment options and a high probability of recurrence. Tumor growth and relapse of TNBC are driven by breast cancer stem cells, and improved therapies that can eliminate those hardy cells are urgently needed. Researchers from the University of Frieburg discovered that coordinated differentiation and changes in the metabolism of breast cancer stem cells make them invisible for the immune system. Counteracting the metabolic change with the drug zolendronate could make immunotherapy using gamma delta T cells more efficient against TNBC. The research team was led by Prof. Dr. Susana Minguet from the Cluster of Excellence CIBSS -- Centre for Integrative Biological Signalling Studies at the University of Freiburg, in collaboration with Dr. Jochen Maurer from the University Hospital RWTH Aachen, Dr. Mahima Swamy from the Universtiy of Dundee/Scotland and collaborators from the University Hospital Freiburg. The study was published in the Journal Cancer Immunology Research, a journal of the American Association for Cancer Research.

A novel stem cell adhesive using mussels

2023-05-23 - 2023-05

Cartilage is a tissue that protects bones by providing shock absorption and facilitates smooth joint movement. Unfortunately, due to its limited intrinsic healing capacity, stem cell transplantation is a promising therapeutic approach to address cartilage inflammation and damage, as well as to promote cartilage regeneration. However, a major limitation of this technique is the rapid disappearance of transplanted stem cells from the smooth cartilage surface and fluidic environment around cartilage, resulting in less effective treatment outcomes. Recently, a joint team of researchers from POSTECH, Dongguk University Medical Center, and Nature Gluetech in Korea has developed a novel treatment strategy for damaged cartilage, involving the use of a viscous immiscible liquid that is capable of facilitating the transplantation of stem cells into affected tissue by means of adhesive protein derived from mussels and hyaluronic acid.

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Scientists discover a new mechanism to generate cartilage cells

Ancient disease has potential to regenerate livers

Cancer stem cells are fueled through dialogue with their environments

A high-fat diet in pregnant monkeys impairs fetal blood stem cells

A look inside stem cells helps create personalized regenerative medicine

Gamma delta T cells can fight aggressive breast cancer

A novel stem cell adhesive using mussels

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Agenda

Tissue Engineering and Regenerative Medicine

Scientists discover a new mechanism to generate cartilage cells

Ancient disease has potential to regenerate livers

Cancer stem cells are fueled through dialogue with their environments

A high-fat diet in pregnant monkeys impairs fetal blood stem cells

A look inside stem cells helps create personalized regenerative medicine

Gamma delta T cells can fight aggressive breast cancer

A novel stem cell adhesive using mussels