Title: Evaluation of Autologous Bone Marrow Derived Stromal Cell Therapy on Spinal Cord Injury in Companion Animals

Abstract:

Pet animals are vulnerable to spinal cord injuries, which are frequently accompanied by significant sensory and locomotor problems and can progress to irreversible paralysis. Through differentiation into neurons and related glial cells, stopping immunological attacks, preventing apoptosis and necrosis, and secreting neurotrophic substances that promote the regeneration process, stem cell therapies provide hope for healing spinal cord injuries. The study aimed to assess the effectiveness of a single intrathecal/intravenous injection of autologous bone marrow-derived stromal cells in a platelet-rich plasma carrier for a subset of clinical cases involving chronic spinal cord injury in dogs and cats. During clinical trials, stem cells were injected into Five dogs and three cats who had spinal cord injuries caused by disc protrusion and those who had not responded to traditional treatment. Three dogs suffered from degenerative Myelopathy for 2 years with no response to treatment, two dogs suffered from Hemiplegia following spinal surgery, and one tetraplegic dog. According to the results, physical therapy combined with the transplanted cells allowed for the restoration of weight-bearing locomotor function and spinal reflexes in less than 90 days. The magnetic resonance scans of the extruded discs indicated only slight modifications after the treatment. The combination intrathecal/intravenous injection of bone marrow stromal cells is a safe and effective method for treating chronic spinal cord injury in companion animals, according to the study's findings.

Biography:

Ahmed Nour Eldine Abdallah is a Researcher at the Hormones department in the Stem cell Research Unit at the Medical research and clinical studies institute under  National Research Center. he is affiliated with Animal Health Research Institute, Dokki, Egypt.