Title: Antibiotic resistance patterns of pathogens isolated from clinical specimens in Sana'a Capital City: a one year retrospective study from 2019 to2020

Abstract:

Background :Antimicrobial resistance(AMR) is one of the most a serious global public health threats and the  major clinical microbiological problem affecting the hospitalized and non-hospitalized patients throughout the world and is particularly affecting developing countries including Yemen, where infectious diseases and poverty are endemic and no legislation for antimicrobial uses. The effectiveness of currently available antimicrobials is decreasing as a result of increasing resistant strains among clinical isolates. Information  on the type of common circulating pathogens with their AMR patterns in a given area is essential for optimal patient care.

Objectives The aim of this study was to determine the resistance pattern of bacterial and fungal  isolates from different clinical specimens at one  major hospital and two laboratories( one governing and another privet) in the in Sana'a Capital City.

Methods:  A retrospective study was conducted in one major  hospital laboratory and two laboratories (one governing and another privet) in the Sana'a Capital City from January 2019  to January 2020. All culture and antimicrobial susceptibility test by disc diffusion method  results of patients who presented at each of the laboratories for  Urine , pus from( deep and surface wounds) Urogenital  ( Urethral discharge, HVS, Seminal fluid , vaginal  and cervical swabs),),(Ear, Nasal ,throat &mouth swabs) ,CSF, Body fluids and stool . Data were analyzed using SPSS Windows version 20.0. The comparisons between different isolates’ resistance to antimicrobials were performed using the chi-square test.