Title: Comparison of E/E' , left atrial volume index and pulmonary artery hypertension in patients with hypertensive induced left ventricular hypertrophy

Abstract:

Aim: We evaluated the prevalence of LA enlargement (LAE) and the relationship  with left ventricular (LV) mass and diastolic function in subjects hypertensive induced left ventricular hypertrophy referred to an echocardiographic study for routine clinical indications.
Method: 100 patients underwent a comprehensive echo-Doppler examination. LAE and LV hypertrophy (LVH) were defined as LA volume index (LAVI) >29 ml/m² and LV mass index (LVMI) >50 g/m² respectively. Abnormalities of LV relaxation and LV filling were diagnosed by age-related thresholds of early mitral flow velocity to Ei ratio (E/Ei) ≥16, respectively.
Result: According to our study, we found that the measurement of E/Ei derived from medial mitral annulus estimated better .It also supports that E/Ei is one of the best Doppler echocardiographic parameter to estimate diastolic function. E/Ei and LAVI  were estimated for patients with Concentric Left ventricular hypertrophy  as well as normal patients. In our study, LAVI correlates better with Grade of diastolic dysfunction.LAVI  is greater in patients with high  E/Ei ratio.  Age, height, weight  was found to be associated with high LAVI. Other studies have shown that the older age group patients are more prone to left atrial enlargement. Patient with Diabetes mellitus (DM), hypertension (HTN) ,Chronic Kidney Disease (CKD) are associated with diastolic dysfunction, that shows raised E/Ei  Therefore non-invasive tissue Doppler measurement of  E/Ei can be used to stratify the risk of the patients.

Conclusion
100 Consecutive patients were included in the study and patients with Atrial fibrillation and significant Mitral regurgitation were excluded.Diastolic dysfunction contributes for Left Atrial Remodelling.LAVI  increases as an expression of diastolic dysfunction More E/Ei , increase chance of  getting Left atrial enlargement in advanced diastolic dysfunction coexist with pulmonary artery hypertension which eventually leads to left sided Heart failure.

Biography:

Syed Ali Afrin is a student intern of Sri Ramachandra Institute of Education and Research, India