Title: Complex Interlinked Connections between Stage-I Hypertension & Genetic factors.

Abstract:

Hypertension is considered to be a complex trait to which genetic, environmental, and demographic factors contribute interactively. Recently, molecular genetic studies have achieved remarkable success in the elucidation of causative mutations in several Mendelian hypertensive disorders in which single nucleotide polymorphisms (SNPs) disrupt the function of single genes, thereby leading to unambiguous phenotypes. It seems unlikely,however, that such a simple base substitution is the primary mechanism in cases of Stage- I Hypertension, even if SNPs modify the relevant gene function to some extent. Despite the enormous  efforts  made  to  date,  no  consistent association  between  any  of  the candidate genes and essential hypertension has been established. One plausible explanation is that because individual genes play a modest role in the pathogenesis of  hypertension,  confounding variables, whether individual (sex, ethnic origin, etc.) or environmental, may decrease the chance of  identifying  a  causative  relation  between  the genes and hypertension, depending on the populations studied. Several approaches can be proposed  to  overcome  this  problem,  including long-term follow-up of clinical events collected to  attain  sufficient  phenotypic  information  and statistical  power.  With  the  recent  advances  in high-throughput genotyping techniques and bioinformatic strategies, it has become possible to perform even SNP-based genome-wide screening.  At  present,  however,  the  need  for identification of susceptibility genes for hypertension still poses a great and unanswered challenge.  Identifying  further  genes  probably conferring even smaller attributable risks represents a major challenge for future developments in this area.This contrasts markedly  with  the  success  that has been achieved in the past 5 years in solving the  molecular genetics  of  a  number  of  rare familial hypertension syndromes. The true incidences  of  some  of  these  disorders  may  be higher than first appreciated, but it is still unclear  if  the  genes  for  these  syndromes  also play  a  part  in  Stage-I  Hypertension.  A  more complete  understanding  of  the  genetic  basis  of essential hypertension should be possible in the coming years using new strategies that take advantage of  the  information  provided  by the human genome project.

Biography:

 Dr. Sunil Pal has completed his B.A.M.S graduation at the age of 24 years from Rajiv Gandhi University of Health Sciences (Bangalore), India. He is now pursuing post graduation in M.D. Kayachikitsa (Internal Medicine- Ayurveda) from Maharashtra University of Health Sciences (Nashik), India. He has over 9 international Publications with 2 abstract as titled in souvenir in his post graduation academics period. Recently he has been awarded with “Bharat Gaurav Puraskar 2021” and “Certificate of Excellence” for outstanding contribution in the field of “Ayurveda Physician”. Recently nominated as “Young Scientist” & “International Scientist” by VDGOOD foundation, coimbatore & Als nominated as “National Excellency Award” by KTK Foundation, New Delhi. He has won many prizes in Quizzes, Paper presentations, poster presentations, essay writings, article writings etc. He is active member of N.Y.L.P. NGO, Mumbai, India also supporting member of AAPNA (Association of Ayurvedic Professionals of North America, USA). He is currently doing research trial on Gokshura (Tribulus terrestris) herbs in Stage-I Hypertension. He is determined to pursue Academia Research. He is enamored of teaching and Clinical Research. He has main interest in Blood disorders, Neurology Auto-immune disorders, Oncology, Nephrology in Ayurveda.