Title: Natural molecules are plausible therapeutic leads to the major protein targets of SARS- CoV-2: Insights from computational modelling and molecular dynamic simulation studies

Abstract:

While significant efforts are in progress for developing drugs and vaccines against COVID-19, limited therapeutic agents are available to curtail this ever-witnessed pandemic. Thus, it is essential to screen novel therapeutic interventions in which structure-based drug discovery and high throughput screening of potential lead molecules paves significant insights. This study focused to predict the binding potential and interaction mechanisms of some natural molecules to the selected putative molecular targets of SARS-CoV-2 by molecular modeling, molecular docking and dynamic simulation studies. One the basis of database search and functional role in COVID-19, fourteen prospective targets were screened and the native structures of three targets that lack experimentally solved structures were computationally modeled and validated. The drug-likeliness, adsorption, distribution, metabolism and excretion (ADME) and toxicity features of selected natural compounds were computationally assessed.

Biography:

Sinosh Skariyachan, is working as Assistant Professor in the Department of Microbiology, St. Pius X College Rajapuram, Kasaragod, Kerala, India. He has pursued his post graduations in Microbiology (M. Sc) and Bioinformatics (M. Sc) and obtained his Ph. D in Biotechnology. He has sixteen years of experience in teaching and research. His key research domains are Computational Biology & Bioinformatics, Molecular Modeling and Computational Drug Designing, Chemoinformatics, Genomics and Proteomics and Medical Microbiology and infectious diseases. He is the member of 17 National and International scientific and professional societies. He has authored 56 International papers, 76 conferences proceedings, one text book and 8 invited book chapters. He has received several awards and travel grants for his research. He is the associate editor of Computers in Biology and Medicine (Elsevier) and serves as editorial board member for six international journals and reviewer for more than hundred plus international journals published by reputed publishers. He has received grants from various funding agencies and honored as plenary speaker in various National and International conferences and symposiums.

Title: Suppression of the reproduction of the influenza virus

Abstract:

According to the WHO, influenza is one of the most pressing problems in world health. Every year, about 500 thousand people die due not only to the infection itself, but also from the complications it causes. Because of their high variability, influenza viruses rapidly develop resistance to many traditional anti-influenza therapies. The development of drugs based on the mechanism of gene silencing using siRNA is a promising direction. Objective: To assess the decrease in viral reproduction in cells with reduced expression of the genes of the nuclear-pore complex Nup98 and Nup205. Materials and methods. Viruses. We used the influenza A / WSN / 1933 virus strain (St. Jude's Children's Research Hospital, USA). Cell lines. A549 cell culture - human lung adenocarcinoma (ATCC CCL-185, USA), MDCK cell culture – dogs ren (Institut Pasteur, France). siRNA.

Biography:

Evgeny Pashkov is a researcher at the Laboratory of Molecular Immunology of the I. I. Mechnikov Research Institute of the Russian Academy of Sciences and an assistant at the Department of Microbiology, Virology and Immunology of the I. M. Sechenov First Moscow State University (Sechenov University). Currently, he is studying at the Department of Microbiology, Virology and Immunology of Sechenov University. Evgeny has 1.5 years of state practice as a researcher and teacher and 3 years as an assistant surgeon at the N. V. Sklifosovsky Research Institute. Evgeny is passionate about fighting viral infections on an international scale.

Title: Establishing an efficient contamination control in Pharmaceutical

Abstract:

Sterility is a key quality attribute for a class of medicines required to be sterile. The consequences of non-sterility are direct patient harm. The degree of harm is dependent upon the route of administration and the types and numbers of microorganisms, as well as the health and immune state of the patient. The likely outcomes of the administration of a non-sterile product are disability or death. For this reason, contamination control is an important part of both sterile and non-sterile pharmaceutical manufacturing, regulators, as signaled by the revised EU GMP Annex 1 and from FDA inspections are increasingly expected the contamination control to be devised and presented as a formal program. This means a detailed, facility-specific contamination control strategy. Therefore, the objective is to develop a robust program that reviews, assesses, and reaffirms strategies for the prevention & remediation of contamination risks. This paper sets out the key elements of the strategy. To be effective, this needs to be an approach that can assess seemingly isolated contamination events holistically and which is capable of putting appropriate corrective and preventive actions (CAPAs) in place. This approach signals a new paradigm in terms of contamination control, shifting the risk review process to one that assesses the impact of a contamination event in a far wider context.

Biography:

Zeinab El-Zein has completed a master's degree in biochemistry from the Lebanese University faculty of sciences. Being a quality-oriented & talented Microbiology Supervisor with up to 8 years of experience in this field,  her expertise is particularly in the areas of quality management, auditing, compliance, quality improvement, and change processes. Throughout her career, she has held various positions. From this frame of reference, Zeinab El-Zein has a quick insight and overview in organizations related to processes and their link to quality.