Title: Suppression of the reproduction of the influenza virus

Abstract:

According to the WHO, influenza is one of the most pressing problems in world health. Every year, about 500 thousand people die due not only to the infection itself, but also from the complications it causes. Because of their high variability, influenza viruses rapidly develop resistance to many traditional anti-influenza therapies. The development of drugs based on the mechanism of gene silencing using siRNA is a promising direction. Objective: To assess the decrease in viral reproduction in cells with reduced expression of the genes of the nuclear-pore complex Nup98 and Nup205. Materials and methods. Viruses. We used the influenza A / WSN / 1933 virus strain (St. Jude's Children's Research Hospital, USA). Cell lines. A549 cell culture - human lung adenocarcinoma (ATCC CCL-185, USA), MDCK cell culture – dogs ren (Institut Pasteur, France). siRNA.

Biography:

Evgeny Pashkov is a researcher at the Laboratory of Molecular Immunology of the I. I. Mechnikov Research Institute of the Russian Academy of Sciences and an assistant at the Department of Microbiology, Virology and Immunology of the I. M. Sechenov First Moscow State University (Sechenov University). Currently, he is studying at the Department of Microbiology, Virology and Immunology of Sechenov University. Evgeny has 1.5 years of state practice as a researcher and teacher and 3 years as an assistant surgeon at the N. V. Sklifosovsky Research Institute. Evgeny is passionate about fighting viral infections on an international scale.