Title: A potential Approach to treat and Prevent Severe Lung Injury Due to Novel Coronavirus (COVID-19) Infection by Blocking TGF1 and MMP-9

Abstract:

Individual infected with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), though the clinical presentation ranges from asymptomatic to mild flu-like symptoms, a significant minority develop severe lung injury with pneumonia, acute respiratory distress syndrome (ARDS) , respiratory failure, systemic inflammation, and multiorgan failure, which leading to considerable morbidity and mortality in the majority of the elderly patients with previous cardiovascular and chronic pulmonary inflammation comorbidities are particularly susceptible to these severe clinical manifestations with coronavirus disease 2019 (COVID-19). Recent clinical and biochemical evidence showing an increase in the levels of Matrix metalloproteinase-9 (MMP-9) in COVID-19 patients. MMP-9 is a matrix-degrading enzyme implicated in many biological processes, including inflammation; MMP-9 has been reported to activate latent transforming growth factor (TGF)-β to its active form and to induce TGF-β production in epithelial cells. TGF-β1 is believed to be a critical mediator of pathologic, fibrotic, and remodeling responses in the lung and other organs, and these responses are believed to be mediated by the ability of TGF-β1 to stimulate fibrogenic and apoptotic “injury” pathways, these observations have led to the suggestion that MMP-9 plays an important role in the tissue remodeling that characterizes many lung diseases.

Biography:

Now I am serving as a Dean of Faculty of Medical and Health Sciences at ECT. I had an overall academic strategic responsibility for establishing many health and medical institutes in Middle East countries. I have possessed a strong teaching background. I have also extensive experience as a researcher in pharmacology, biochemistry, toxicology and clinical pharmacology through the supervision of students and junior pharmacists & other medical-related sciences and researchers