Title: The relationship between plasma total testosterone and metabolic syndrome in male patients

Abstract:

We found that the Prevalence of Hypogonadism was 38.6%. There was a statistically significant correlation between TT and WC, BMI, Glu and decreased HDL-c. The relationships were not statistically significant between TT and TG or BP. so It is important to screen for hypogonadism in metabolic syndrome patients .The results of my study published in the Tishreen University Journal. Link: http://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/8874 Pushed by my willingness to seek more knowledge about obesity, nutrition, and nutritional therapy, I enrolled in and completed many online courses through the Coursera platform. I completed "Easing The Burden Of Obesity, Diabetes And Cardiovascular Disease" offered by the University of Sydney, "Designing Your Personal Weight Loss Plan" offered by Case Western Reserve University, "Weight Management: Beyond Balancing Calories" offered by Emory University, "Nutrition And Lifestyle In Pregnancy" offered by Ludwig-Maximilians-Universität München, "Diabetes - A Global Challenge" and "Diabetes- the essential facts" offered by University of Copenhagen. And to improve my academic skills, I completed "Epidemiology: The Basic Science Of Public Health" offered by The University of North Carolina at Chapel Hill and "Introduction To Systematic Review And Meta-Analysis" offered by Johns Hopkins University. Now I am enrolled in a new course "Understanding Obesity" offered by the University of Edinburg, I am expected to finish this course by December 2019. I am interested in presenting the results of my study or talking about my experience in self-learning online and how that enhanced my everyday clinical practice

Biography:

Dr. Muhtadi Mansour. I got my master's degree in Endocrinology and metabolism in 2019. During my master's, I researched the relationship between total plasma testosterone and metabolic syndrome (Mets) in male patients. I was interested in the metabolic syndrome because it is more prevalent than before and a lot of patients achieve the criteria of this syndrome without complaining of major symptoms. It is estimated that the prevalence of metabolic syndrome (Mets) is 20-25% of adults worldwide. On the other hand, Hypogonadism is associated with Mets and it may be a risk factor for type 2 diabetes and cardiovascular diseases. My study aimed to estimate Hypogonadism prevalence in male patients with Mets and study the relationship between plasma total testosterone levels (TT) and the Mets components. It is a cross-sectional study that included 157 patients. Body mass index(BMI), waist circumference(WC), Blood Pressure(BP) and (TT), High-density lipoprotein cholesterol(HDL-c), Triglycerides (TG) and Glucose(Glu) were assessed.

Title: A Medical Nutritional Supplement Improves BMI, Hemoglobin, Fatigue levels in female anemic patients.

Abstract:

OBJECTIVE: The aim of this study was to determine the effect of 3 months consumption of medical nutrition supplement (MNS) in adult anemic females.
BACKGROUND: Globally, anemia affects 1.62 billion people, whereas in India 53.2% of non-pregnant women and 50.4% of pregnant women were found to be anemic in 2018, as per the NFHS. Proper balanced daily nutrition is important for women, which includes adequate levels of essential high-quality proteins, amino acids and complex carbohydrates to help meet adult nutritional needs (1,2). Therefore, in the present study, the short-term effects of MNS rich in proteins, hemo-nutrients and biotin in anemic women were studied.
DESIGN: This was a retrospective observational study where MNS (MaxvidaTM) was given to 226 anemic female subjects between 1st March to 30th April 2019 and evaluated for their clinical data (age, weight, and BMI), Modified Fatigue Impact Scale (MFIS) and hand-held dynamometry (HHD) at 1, 2 and 3 months.  
RESULTS: The mean (SD) age of patients was 31.1 (8.9) years in this study. A significant improvement in BMR was observed from baseline 21.7±0.3 to 22.6±035 at 3 months (p=0.013). Weight was found to increase from baseline 51.3±0.7 to 53.3±0.6 and 53.9±0.6 kg at both 2nd and 3rd months, respectively (p = 0.001). Statistically significant increase in Hb levels was observed from baseline 9.0±0.1 to 11.0±0.1 at 3 months (p=0.001) due to MaxvidaTM intake. There was a significant reduction in MFIS score from baseline 51.1±1.1 to 28.9±1.3 at 3 months (p=0.0001), and improvement in HHD score from 17.3±0.4 to 22.0±0.5 at 3 months (p = 0.001). No serious adverse effects were noticed during consumption.
DISCUSSION: 
Anemic condition in females is increasing throughout the world as the population in most of the countries continues to age, impacting their BMI. This study evaluated the efficacy and safety pattern of consuming   MaxvidaTM. Overall, Hb levels increased by 2.0% (from 9.0 to 11.0) at the end of 3 months with overall statistical increase in BMR. There was also statistical increase in HHD showing increase in muscular response and improvement from fatigue. 
Conclusion: MNS MaxvidaTM was found to be efficacious in improving the anemic conditions in female subjects with no deleterious effects.

Biography:

Pharmacovigilance, Clinical Trials, Regulatory Affairs, Medicine, Healthcare, Clinical Research, Oncology, Diabetes, Medical Writing, Cardiology, Medical Affairs, Pharmacology, Pharmaceutical Industry, Urology, GCP, ICH-GCP, Clinical Development, Pharmaceutics, Life Sciences, CRO, Product Launch, SOP, Regulatory Submissions, Ich Gcp, Strategic Planning

Title: Medical Nutritional Supplement Improves Fatigue levels and muscle strength in adults complaining of generalized weakness and fatigue

Abstract:

OBJECTIVE: The aim of this study was to determine the effect of 3 months consumption of medical nutrition supplement (MNS) in adults complaining of generalized weakness and fatigue.
BACKGROUND: Aging is accompanied by substantial changes in body composition which affects both physical abilities and appearance. After reaching a peak in early adult years, skeletal muscle mass and strength gradually decline 
(1). Despite its high prevalence, fatigue remains an often-neglected symptom. It is usually defined as a state related with the weakening and/or depletion of the individual’s physical and/or mental resources. Fatigue is strongly associated with poor physical performance 
(2). Proper balanced daily nutrition is vital for adults, which includes adequate levels of essential high-quality proteins, amino acids and complex carbohydrates to help meet adult nutritional needs (3,4). Therefore, in the present study, the short-term effects of MNS rich in proteins, hemo-nutrients and biotin in adults complaining of generalized weakness and fatigue were studied.
DESIGN: This was a retrospective observational study where MNS (MaxvidaTM) was given to 289 subjects (aged 18-45 years) between 1st March to 30th April 2019 and evaluated for their clinical data (age, weight, and BMI), Modified Fatigue Impact Scale (MFIS) and hand-held dynamometry (HHD) at 1, 2 and 3 months.  
RESULTS: The mean age of patients was 33.5 years in this study. A significant improvement in BMI was observed from baseline 22.3±0.3 to 22.8±0.2 at 3 months. Weight was found to increase from baseline 55.5±0.7 kg to 57.7±0.6 kg at 3rd months (p = 0.017). Statistically significant increase in Hb levels was observed from baseline 9.6±0.1 to 11.6±0.1 at 3 months (p=0.0001) due to MNS intake. There was a significant reduction in MFIS score from baseline 48.8±0.9 to 31.4±1.2 at 3 months (p=0.0001), and improvement in HHD score from 21.6±0.5 to 26.4±0.5 at 3 months (p = 0.001). No serious adverse effects were noticed during consumption.
DISCUSSION: Poor nutritional status and advancing age can be the contributing factor of fatigue and decrease muscular strength. This study evaluated the efficacy and safety pattern of consuming MNS. Overall, at 3 months, there was a significant reduction in MFIS score by 17.4 points (p=0.0001), and improvement in HHD score by 4.8 (p = 0.001), showing increase in muscular response and improvement from fatigue. Hb levels also increased by 2.0% at the end of 3 months with overall statistical increase in BMR.
Conclusion: MNS used in the study was found to be efficacious in improving the fatigue levels and muscle strength in subjects with no deleterious effects

Biography:

Pharmacovigilance, Clinical Trials, Regulatory Affairs, Medicine, Healthcare, Clinical Research, Oncology, Diabetes, Medical Writing, Cardiology, Medical Affairs, Pharmacology, Pharmaceutical Industry, Urology, GCP, ICH-GCP, Clinical Development, Pharmaceutics, Life Sciences, CRO, Product Launch, SOP, Regulatory Submissions, Ich Gcp, Strategic Planning

Title: Disappointing worldwide obesity treatment statistics: The hCG method deserves an unbiased review

Abstract:

The obesity epidemic is devastating the Social and Healthcare structure of developed and underdeveloped nations. In developed countries, obesity accounts for 1 out of 3 individuals. The medical care costs of obesity in the United States, for example,  are high. In 2008 dollars, these costs were estimated to be $147 billion.  The annual nationwide productive costs of obesity obesity-related absenteeism range between $3.38 billion ($79 per obese individual) and $6.38 billion ($132 per obese individual). Despite this thrilling data, obesity treatment results remain disappointing: gathered data is depressing , from surgical to non-surgical procedures. Short term weight loss does not result in long term weight loss

The hCG method for obesity treatment: an overlooked alternative.

Despite their critics, the hCG (Human Chorionic Gonadotropin) + diet protocol survived for the past 65 years:  clear evidence that the procedure outpassed the test of time. About seventy years ago his author: Dr. ATW Simeons was the first Physician to suggest that the problem of obesity is not related to weight as registered on a bath scale, but in the increased amount of total body fat. The cause for that abnormal fat accumulation does not lies neither in the mouth or the stomach, but in a neuropeptide disorder at hypothalamic level. Recent research on leptins, adiponectins, and neuropeptides sustain his working hypothesis The method provided relief and excellent results to hundreds of thousands of overweight /obese patients worldwide. By 1991, I have developed and published my obtained results using an oral formulation of hCG. Consequently, I have reported over the Internet our research results, both in humans and experimental animals.

To summarize our conclusions:

In human volunteers:

1. Compared to placebo-treated, volunteers submitted to the hCG+diet procedure lost more body fat than their placebo counterparts
2. Perfectly tolerated a Very-Low-Calorie Diet.
3. Rapidly improved their blood sugar levels and blood pressure.
4. No side effects

In experimental animals: compared to placebo-treated: hcg+diet animals significantly:

1. Lost more body fat.
2. Decreased plasmatic Leptin levels
3. Increased adiponectin levels.
4. Decreased blood sugar levels.

Besides, hCG administration has a protective effect on pancreatic beta cells, improves intractable chronic pain, decreased blood pressure more efficiently than patients treated only with hypocaloric diet.

Biography:

Dr. Belluscio devoted most of his medical career to the study of hCG for weight loss.For several years he was a researcher at Bellevue Klinik, Switzerland, an institution with the most impressive records of treated patients with hCG (15,000) for obesity and overweight.He traveled to the U.S., Mexico, Sweden, Italy, Germany, and Israel, lecturing on the method. In 1987 he founded The Oral hCG Research Center, an institution devoted to the utility of hCG for obesity treatment. Records show that the center used the hCG Oral method in over 9.000 patients.Back in 1991, he developed an oral hCG formulation, which demonstrated its effectiveness in a series of Double-blind studies.Together with Dr. Vogt, Director of Bellevue Klinik, published several reports on the method aimed at Healthcare Professionals, and articles on the subject for the general public.OralhCG has been registered as a TM,with patents published and pending, both in Argentina and the United States. These patents and registrations include the brand: oralhCG, as well as various pharmaceutical sublingual formulations. These formulations have been used in his private practice for his patients for over 25 years.Currently, Dr. Belluscio participates in international medical congresses and gives lectures and lectures to the global medical community on the hCG Protocol and the formula he has developed.

Title: Efficacy of different prediabetes program models in improving clinical outcomes in people with prediabetes

Abstract:

Background: Educational programs in general seem to have a clinically significant beneficial effect among the T2DM population in terms of improved glycaemic control. However, few evaluations of interventions to delay or prevent type 2 diabetes mellitus (T2DM) in Saudi Arabia (SA) have been undertaken.
Objective: The present study evaluates for the first time, the differences in the effectiveness of the different educational programs [intensive lifestyle modification (Group Education Program, GEP), supervised education through social media (WhatsApp Education Group, WEP) and standard care via PHCCs (Control Group, CG)], among Saudi females with pre-diabetes.
Methods: This was a 6-month, multi-center, 3-arm cluster, randomised, controlled (1:1:1), multi-intervention study conducted from July 2018 until March of 2019 in Riyadh, SA. A total of 1140 females from SA were cluster randomised equally to three groups, out of which only 253 [N=100 GEP, N=84 WEP and N=69 CG] received intervention. Participants completed questionnaires including demographic, dietary and physical activity data. Anthropometrics, blood samples and dietary intake were collected at baseline and 6 months. A total of 120 [37 CG (age 50.9±7.1 years; body mass index (BMI) 31.6±5.8kg/m²), 40 GEP (age 42.9±12.2 years; BMI 34.8±9.0kg/m²) and 43 WEP (age 43.7±8.1 years; BMI 30±5.1kg/m²)] participants completed the study.
Results: Haemoglobin A1c (HbA1c; primary endpoint) significantly improved in all groups over time, with no difference in between-group comparisons. Between group comparisons adjusted for age revealed a clinically significant reduction in BMI in favour of GEP (p=0.02) post-intervention. A clinically significant reduction was also observed in favour of GEP in terms of weight (p=0.003), waist circumference (p=0.017), systolic and diastolic blood pressure (p-values <0.01), triglycerides (p<0.001) and caloric intake (p<0.005) over time.
Conclusion: Prediabetes education programs of 6-month duration, whether delivered through an intensive lifestyle modification, social media or standard care, are equally efficacious in improving HbA1c levels among Saudi women with prediabetes, but intensive lifestyle is superior in terms of weight reduction and over-all cardiometabolic improvement.

Biography:

Rasha Yousef Al-Hamdan. I graduated from king Saud University, College of Applied Medical Science, Riyadh, Saudi Arabia, with Bachelor degree of 4,47/5 in Clinical Nutrition since 2001. I worked in my field as a dietitian in the private and government sectors.