Title: The lack of fam83h mediated reduction of wnt/?-catenin signaling pathway and expression levels of dental mineralization genes

Abstract:

Background: FAM83H has been identified as an essential gene for dental enamel formation and may be related to Wnt/β-catenin. Methods: levels of Fam20a, Dspp, Dmp1, Enam, Ambn, Sppl2a, Mmp20, Fgf10, and the mediators of Wnt/βcatenin pathway were measured in the dental root of both Fam83h-KnockOut and wild-type mice by using QPCR at 5,11 and 18 days after birth. The expression of Fgf10 and the mediators of Wnt/β-catenin were also evaluated in the skin of KnockOut and wild-type mice by using Q-PCR and also, The histology of hair follicles was compared. the Fam83h-KnockOut mice recruited in this study confirmed by Sanger sequencing and western blot analysis. Results: Our results showed that Ambn, Mmp20, Dspp, and Fgf10 significantly reduced in Fam83h-KnockOut mice in the dental root, associated with marked reduction of CK1a, CK1e, and β-catenin expression in Fam83hKnockOut mice in the dental root. The Fgf10, CK1a, CK1e, and β-catenin were significantly decreased in the skin of Fam83h-KnockOut mice. In the absence of Fam83h, the accumulation of unemployed CK1a is expected to elevate the β-catenin destruction complex. The reduction of CK1e may also decrease the signaling of Dvl-1, leading to the suppression of the Wnt/β-catenin pathway. Simultaneous reduction of both mineralization genes and Wnt/β-catenin pathway due to the absence of Fam83h has a potential to be related to the deficiency of dental formation and mineralization. Further, concurrent reduction of Fgf10 gene expression and Wnt/β-catenin pathway may also affect the maturation of hair follicles as confirmed by histological examination. Conclusion: it seems that in the lack of Fam83h, dental mineralization is induced by simultaneous decrease of Wnt / β-catenin mediators and the mineralization-related genes, suggesting to act in a cumulative effect manner and probably behave as a multi-factorial trait.

Biography:

Sheikh Sabrina, an Assoc. Prof. In Azerbaijan Medical University, 1966. In 1988, graduated Az. Med.University pharmaceutical faculty. In 1988-1993 worked on the theme "Atherosclerosis correction by triterpenoids". Ph.D. in biological science. Nationality: Azerbaijani, Is a co-author of 2 books: "Biochemical laboratory classes" and " "Biochemistry laboratory manual and theory and methods", an editor of book "Pathological and clinical biochemistry" An author of teaching aids: "Biochemical mechanism of biotransformation and elimination of xenobiotics" An author of teaching aids: " Biochemical aspects of aging", "Some points in biochemistry and pathobiochemistry of the cell", "Role of apoptosis in the pathogenesis of certain diseases", "Biochemical aspects of ethanol action and metabolism", An author of annual biochemistry test-books for students of treatment, dental, pharmaceutical faculties, and test-book in clinical biochemistry. An expert in "State Commission for post-graduates"

Title: Prevalence, risk factors and antibiotic resistance of staphylococcus aureus and mrsa nasal carriage among healthy population in ibadan, Nigeria

Abstract:

Objective: By the lack of initiative by force (Faith) Iron man lives. Iron deficiency causes anemia, anemia causes dementia, Alzheimer's dementia and Alzheimer’s produces cognitive impairment in memory produces bases. Well, hear him. The Iron Will Alkaline, the answer is yes. Methodology: On the basis of Love and the use of Iron and its allies, which are the B vitamins, Vitamin C, E, and vitamin A. It is necessary to remember that there is to try to fight the greatest sustenance Anemia in all its contrarestantes. Conclusion: The theory focuses on the oxygenation of the blood, which must be done, where the Warburg Alkaline Diet is demonstrated, among other factors it is necessary to emphasize the oxygenation that consists of the mental and physical, which is reduced in Sleeping correctly, Warburg Alkaline Diet, Drink Enough Water, Make Walks or Moderate Exercises, Comfort and Drink Iron, Vitamin C, Vitamin E, Complex B and Vitamin A. All this consists in Producing New Oxygen.

Biography:

Joan Manuel Rodriguez Nunez is the creator of global zionist nemruthism and towards moral sociology: historical measurementism. He has done more than fifteen theories and a cure: alz, cancer, toe.

Title: Facial detection and recognition in social networks (Images, videos)

Abstract:

The ultimate goal of prosthodontic treatments should be to regenerate the missing teeth together with the periodontal structures. Many prosthodontists have thought “I could have achieved a better treatment outcome if regenerative therapies were more readily available.” To date, prosthodontists have been managing missing teeth/alveolar bone by “replacement prosthodontics” using artificial materials such as dentures and dental implants. Recent development of stem cell-based regenerative medicine has introduced the concept of “regenerative prosthodontics” to our field, particularly in cases of missing teeth with severe alveolar bone resorption. This is mainly possible with the help of stem cells. Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide to produce extra stem cells. They are originated in multicellular organism. They may be embryonic or adult stem cells. The stem cells of the dental pulp are the mesenchymal stem cells (MSC). They are the most commonly used stem cells. However, bone marrow-derived mesenchymal stem cells are a commonly used cell type for utilization in cell-based regenerative approaches in prosthodontics. They help to build the bone structures of the craniofacial region, particularly the maxilla and mandible. Stem cell therapy is one the most recent advances in the dental field. Its use establishes a 100% success rate. Thus, knowing its value is of prime importance. The presentation includes various challenges in relation to regenerative therapies being used as well as recent trends n regenerative prosthodontics.

Biography:

Sherko Nasseri is doing a Ph.D. in molecular medicine. Assistant Professor, from Kurdistan University of Medical Sciences, Iran. During my Ph.D. Thesis, I worked on the generation of Fam83h Knockout Mice by using the CRISPR/Cas9 method. The absence of Fam83h these mice has the scruffy cover, dry eye phenotypes, and also these mice were smaller than the same age normal mice. In continuation of this project, we found that the WNT/B-Catenin pathway decreased. The Fam83h gene has a high expression level in the gastrointestinal tract. Given all that has been said, it brings me a critical question that how does the fam83h gene play role in the gastrointestinal tract?