Title: The Lack of Fam83h Mediated Reduction of Wnt/?-Catenin Signaling Pathway and Expression Levels of Dental Mineralization Genes

Abstract:

Statement of the problem: Cancer is a multifaceted disease that deals with the proliferation of tumor cells and becomes fatal for thousands of lives because of its treatment that still remains challenging for the scientific community. The only nanoparticle is not subjected to cancer treatment Methodological and theoretical orientation: At the same time, nanotechnology is becoming the emerging field of recent developments in medicine which is a very essential part of the failure of pharmaceuticals nowadays. In this study, silver oxide nanoparticles have been synthesized through the co-precipitation method and functionalized with the ant-cancer drug. This synthesis is confirmation via different characterizations X-ray Diffraction (XRD), Fourier Transformed Infrared (FTIR), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), and Ultraviolet (UV) spectroscopy and uses them against cancer cell lines that will help to opine the treatment of cancer and save thousands of precious lives. Findings: Silver oxide nanoparticles have improved the drug delivery and synergistic effect with drugs. One of the functionalized formulations shows better results even at very low concentrations on HepG2 cancer cell lines with very low IC50 as compared to others. Similarly, this combination showed very low relative percentage viability, and very few cancer cells were shown when used against cancer cell lines. Such kind of combination of nanoparticles to the anti-cancer drug will provide a very convenient way to find out the cancer treatment. Conclusion and significance: The combined effect of nanoparticles with the anti-cancer drugs has been observed as a very effective treatment against cancer.

Biography:

Nosheen Rehman has her expertise in research passion in finding cancer treatment. Her open and experimental focus by using nanoparticles creates new pathways for improving the treatment of cancer. She has completed this research from hospitals and different educational institutions. The potent anti-cancer effects of silver NPs inspired us to explore the antitumor potential of silver oxide NPs in a number of tumor cell lines (Banerjee et al. 2017) which makes a non-conventional treatment for cancer. It will make the safe side for the body that might be damaged by chemotherapies. This approach is responsive to all pharmacists and has a different way of focusing on better treatment of cancer as well as patients will facing least radioactive damage.

Title: Establishing an efficient contamination control in Pharmaceutical

Abstract:

Sterility is a key quality attribute for a class of medicines required to be sterile. The consequences of non-sterility are direct patient harm. The degree of harm is dependent upon the route of administration and the types and numbers of microorganisms, as well as the health and immune state of the patient. The likely outcomes of the administration of a non-sterile product are disability or death. For this reason, contamination control is an important part of both sterile and non-sterile pharmaceutical manufacturing, regulators, as signaled by the revised EU GMP Annex 1 and from FDA inspections are increasingly expected the contamination control to be devised and presented as a formal program. This means a detailed, facility-specific contamination control strategy. Therefore, the objective is to develop a robust program that reviews, assesses, and reaffirms strategies for the prevention & remediation of contamination risks. This paper sets out the key elements of the strategy. To be effective, this needs to be an approach that can assess seemingly isolated contamination events holistically and which is capable of putting appropriate corrective and preventive actions (CAPAs) in place. This approach signals a new paradigm in terms of contamination control, shifting the risk review process to one that assesses the impact of a contamination event in a far wider context.

Biography:

Zeinab El-Zein has completed a master's degree in biochemistry from the Lebanese University faculty of sciences. Being a quality-oriented & talented Microbiology Supervisor with up to 8 years of experience in this field,  her expertise is particularly in the areas of quality management, auditing, compliance, quality improvement, and change processes. Throughout her career, she has held various positions. From this frame of reference, Zeinab El-Zein has a quick insight and overview in organizations related to processes and their link to quality.

Title: Controlled Drug Delivery Based On Biocompatible Polymeric System

Abstract:

Several metallic microbotic actuators have been developed in the recent past, that have enabled the target oriented advanced drug delivery system (DDS) for specific applications like cancer and gastrointestinal medication. The method involves the use of microbots or actuators that contain drugs and enable the controlled drug delivery at the site based on temperature, pH, light, electric and magnetic field sensitivity. Other techniques were based on single or combination of above-mentioned criteria. The materials used for actuators or microbots either lack in delivering required amount of drug or it does not retain inside the body for long. To overcome these problems, we are interested in providing better solutions to it by using suitable gripping technique and polymeric system for long term exposure, with controlled release of sufficient drugs at site. The application of polymers showed that these responsive materials can overcome addressing limitations associated with metals used in a wide array of medical devices in the novel drug delivery system. Amphiphilic polymers have played a key role in the development of advanced drug delivery technologies by controlling solubility, permeability, and stability of active ingredients. Amphiphilic polymers possess the ability to encapsulate hydrophobic drug molecules inside their hydrophobic core, hence increasing the aqueous solubility of the drug. The problem of controlled drug delivery of polymeric systems could be achieved by embedding nanofillers to it. The polymeric nanocomposites could form a tortuous path for diffusion of drugs through it due to the impermeable particles in it, leading to enhancement of the controlled release rate. Various tortuous path models have already been developed that specifies the diffusion rate of solutes through such composites. The oral route is considered the most preferable route for drugs administration. While encapsulation could be done for the drug transport for oral route, the solution to its retention lies in the spiked surface structure similar to the orchid that would be responsible for its attach to the intestinal surface.

Biography:

Sana Zahra has done MSc in Applied Biochemistry in 2010 (Gold Medalist). With a better record in earlier studies and an interest in research, she is trying to get back into research even after a long-term gap in her studies.